Pharmacology: Pharmacokinetics: Lamotrigine is well absorbed from the gastrointestinal tract and peak plasma concentrations occur approximately 2.5 hours after oral administration. It is widely distributed in the body and is 55 % reported to be about 55% bound to plasma protein. It is extensively metabolized in the liver and excreted almost entirely in the urine, principally as glucuronide conjugate. It slightly induces it own metabolism and the half-life steady state is reported to be about 24 hours. Lamotrigine is distributed in the breast milk.
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